The Science Behind The Sinclair Method and Why It Is So Successful

As a result of your genetic predisposition and learned behavior, you may receive overwhelming positive reinforcement from the chemicals in your brain each time you drink. This reinforcement results in an inability to drink moderately. It also results in damage to your life, your family, your job and your personal reputation. You can't control the way you are "wired" but you can do something about it. You can take control of your drinking and your life.

At The Moderation Institute, we incorporate The Sinclair Method into our three-stage treatment. The Sinclair Method utilizes medication to reduce the positive reinforcement that is generated by your brain when you drink. In tandem with the medication we administer, strategic one-on-one targeted therapy focuses on the most crucial underlying issue and strongest triggers. We then implement practical tools to regulate negative thoughts that trigger your desire to drink. Last, we help you program new behaviors into your life which replace problematic behaviors. The end result of the program is the ability to live life in a happier, healthier way without the reliance or need for alcohol.

 Moderation Method-3-Stage Alcohol Treatment Program


Over time, and with enough repetition, the potent positive reinforcement your brain generates when you drink results in your difficulty or complete inability to moderate the amount you drink. The Sinclair Method, incorporated into your treatment, utilizes the medication Naltrexone. Taken prior to drinking, it reduces that positive enforcement. For over twenty years, the incredibly effective use of Naltrexone via The Sinclair Method improved the lives of many people. Learn more...



Through the use of strategic one-on-one cognitive behavioral therapy and ACT therapy, you will able to address your core issues and triggers. A trigger is a primary thought, feeling, or combination of both directly linked to your increased desire to rely on unhealthy habits. Some examples of triggers include the following:

-low self-esteem


-social anxiety

-lack of healthy coping tools



-past trauma

-relationship issues

The targeted trigger elimination works by identifying, eliminating, and ultimately changing the behaviors involved in driving your unwanted drinking patterns. Equally as important, is the targeted therapy that re-programs your maladaptive thought patterns that also are driving your drinking. Together, through improving your behavior and your thoughts, you will re-gain control over alcohol. Learn more...


The creation of healthy new behaviors will help replace the undesirable habits that get in the way of being your best self. These may include a healthy diet, exercise, recreation and more.

As you move through the program, you will find yourself not drinking every day (if you aren’t already). On days when you are not taking Naltrexone (non-drinking days) your brain will respond more favorably to healthy behaviors. This is accomplished through a process involving selective reinforcement. 

The powerful combination of medication, therapy and new healthy behaviors that we deliver results in an 80% success rate for the program.
— Dr. Michael Yasinski, M.D., Founder, The Moderation Institute


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